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ORIGINAL ARTICLE
Year : 2017  |  Volume : 22  |  Issue : 2  |  Page : 83-88

Correlation between smoking, serum serotonin level, and peripheral fatigue of back extensors: cross-sectional study


Department of Basic Science for Physical Therapy, Faculty of Physical Therapy, Cairo University, Cairo, Egypt

Correspondence Address:
Ghada I Mohamed
Department of Physical Therapy Basic Science, Faculty of Physical Therapy, Cairo University, 7 Ahmed Elzayyat St., Dokki, Giza 12613
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bfpt.bfpt_3_17

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Background Smoking is a negative behavior pattern that is harmful to our life .When the spinal muscles are fatigued, their capacity to create a quick extensor movement is compromised, and serotonin is the master regulating hormone in the body that controls distinctive body works for instance. Purpose This study was conducted to investigate the relation of serum cotinine level (the metabolite of nicotine), serum serotonin level, and peripheral fatigue of back extensors. Patients and methods A total of 60 (40 smokers and 20 nonactive smokers) normal men were assigned into three groups: 20 nonsmokers (control group), 20 moderate smokers, and 20 heavy smokers. Blood samples were taken from all patients to analyze cotinine and serotonin levels by laboratory tests. Isokinetic dynamometer was used to measure fatigue susceptibility by calculating the fatigue index. Results There was a statistically significant correlation among serum cotinine level, fatigue index, and serum serotonin level in heavy smokers (P<0.05) and in moderate smokers (P<0.05). In addition, there was a significant correlation between serum cotinine and serotonin levels in the nonsmoker group (P<0.05). Conclusion An increase in the serum cotinine level increases the fatigability of back extensors in smokers. Further, cotinine has an inverse relationship with serum serotonin level in smokers and nonsmokers. In addition, serum serotonin level had an inverse relation with peripheral fatigue of back extensors in smokers.


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